• Male subjects between 22 and 65 years of age

• Subject diagnosed with a stricture in the anterior urethra that is able to be treated with the Optilume Urethral DCB in accordance with the approved Instructions for Use

• Subject is willing to provide written informed consent and comply with study required follow-up assessments

• Subject able to provide viable semen samples and baseline semen quality characteristics are above reference values based on below criteria (average of 2 samples):

‣ total sperm ≥39 million

⁃ sperm concentration ≥15 million/mL

⁃ total motility ≥40%

⁃ progressive motility ≥32%

⁃ morphology ≥4%