Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence
Who is this study for? Older adult female patients with Urinary Incontinence
What treatments are being studied? Trospium
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
This is a randomized double-blind crossover trial of trospium and placebo in women with urgency urinary incontinence, with evaluation (history, physical, incontinence evaluation and brain MRI) at baseline, and after each course of therapy. The investigators will evaluate functional brain changes in relation to bladder improvement in order to improve our knowledge of the brain's role in the continence mechanism.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 60
Healthy Volunteers: f
View:
• 60+ years old
• Has UUI or urge-predominant mixed incontinence at least 5 times/ week for \> 3 months despite treatment for reversible causes
Locations
United States
Pennsylvania
University of Pittsburgh
RECRUITING
Pittsburgh
Contact Information
Primary
Becky Clarkson, PhD
bdc29@pitt.edu
412-647-1270
Time Frame
Start Date: 2020-02-13
Estimated Completion Date: 2025-10-30
Participants
Target number of participants: 220
Treatments
Experimental: Placebo/Trospium
Placebo first for 12 weeks followed by Trospium for 12 weeks.
Experimental: Trospium/Placebo
Trospium first for 12 weeks followed by Placebo for 12 weeks
Authors
Neil Resnick
Related Therapeutic Areas
Sponsors
Collaborators: National Institute on Aging (NIA)
Leads: Becky Clarkson