• patients with idiopathic Parkinson's disease were diagnosed by experienced neurologists based on the diagnostic criteria of the International Motor Disorder Association.

• PD patients with overactive bladder were observed by voiding diary for 3 days and evaluated by OABSS score.

• Eligible males and females, aged between 25 and 80.

• The patient was treated with dopaminergic drugs, and if there was an wearing-off phenomenon, it was evaluated during the turning-off period or without taking the drug (when the patient developed one of the symptoms in WOQ-19 \[13\] and the symptom improved after the next medication, it suggested that there was an end-of-dose phenomenon).

• With a history of NDO ≥ 3 months, the symptoms of bladder overactivity were not fully controlled by anticholinergic drugs, which was defined as insufficient response after 4 weeks of treatment or unbearable side effects after 2 weeks of optimized dose treatment.

• patients who took anticholinergic drugs at baseline must maintain a stable dose throughout the study, while those who did not take anticholinergic drugs could not take them during the study period.

• if necessary, the patient must be willing to initiate intermittent catheterization (CIC).

• the informed consent of the subject or his guardian has been obtained, and the informed consent of the clinical trial has been signed voluntarily.