Training for Urinary Leakage Improvement After Pregnancy

Status: Recruiting
Location: See all (7) locations...
Intervention Type: Device, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a multi-center, randomized single-blind nonsurgical trial conducted in approximately 216 primiparous postpartum women at high risk for prolonged/sustained pelvic floor disorders with symptomatic, bothersome urinary incontinence (UI) amenable to nonsurgical treatment. TULIP is a 3-Arm trial with two active interventions (Arms 1 and 2) and a Patient Education control arm (Arm 3). Arm 1 consists of pelvic floor muscle training (PFMT). Arm 2 uses a home biofeedback device (leva®). The primary outcome will be assessed at 6 months postpartum by blinded outcomes assessors, and follow-up will continue until 12 months postpartum.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:

• ≥18yo primiparous patient s/p singleton vaginal delivery (\>32 weeks), approximately 6wk postpartum

• At increased risk of sustained pelvic floor disorders, as defined by

‣ neonate ≥3.5kg, and/or

⁃ operative delivery (i.e., forceps or vacuum-assisted vaginal delivery), and/or

⁃ ≥2nd-degree perineal laceration

• Symptomatic, bothersome UI as defined by a score of ≥6 on the ICIQ-SF.

Locations
United States
California
Kaiser Permanente -- San Diego
NOT_YET_RECRUITING
San Diego
University of California - San Diego
RECRUITING
San Diego
Illinois
University of Chicago
RECRUITING
Chicago
North Carolina
Duke University, Duke Division of Urogynecology and Reconstructive Pelvic Surgery
RECRUITING
Durham
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
Rhode Island
Brown/ Women and Infants Hospital of Rhode Island, Center for Women's Pelvic Medicine and Reconstructive Surgery
RECRUITING
Providence
Texas
University of Texas Southwestern Medical Center
RECRUITING
Dallas
Time Frame
Start Date: 2024-11-12
Estimated Completion Date: 2027-11-12
Participants
Target number of participants: 216
Treatments
Active_comparator: Interventionist-guided training
Interventionist-guided training at baseline (i.e., approximately 8 weeks postpartum), followed by a Home Exercise Prescription (HEP), a second interventionist-guided training session approximately 4 weeks later, and then continued HEP. Two exercise sets per day are encouraged between baseline and 6 months postpartum (i.e., time of the primary outcome), followed by at least 3 times-per-week exercise sets until 12 months postpartum. Home exercises will be encouraged using a PFDN research smartphone app, resources to help participants with home exercises and prompts for participants to confirm the number of exercise sets completed.
Active_comparator: Home pelvic floor exercises guided by the leva® device
Home pelvic floor exercises guided by the leva® device and its accompanying app/software for gradually increasing strength and duration of pelvic floor contractions. The PFDN research smartphone app will have weekly queries of whether exercises were completed.
Other: Education
Education will be provided on pelvic floor muscle function and continence mechanisms. No specific prescription or verbal direction will be given regarding the suggested number and frequency of home pelvic floor muscle exercises.
Related Therapeutic Areas
Sponsors
Collaborators: University of Pennsylvania, University of California, San Diego, RTI International, Duke University, University of Chicago, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Kaiser Permanente, University of Texas Southwestern Medical Center, Women and Infants Hospital of Rhode Island
Leads: NICHD Pelvic Floor Disorders Network

This content was sourced from clinicaltrials.gov

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