Intravenous Versus Oral Treatment of the Main Acute Infections in Emergency Departments

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Patients admitted to the hospital with acute infections are often treated with intravenous (IV) antibiotics. Around 70% of these infections fall into three categories: respiratory tract infections, urinary tract infections, and cellulitis. A Danish study found that 76% of patients admitted with suspected community-acquired pneumonia and treated with antibiotics received them intravenously. Based on an extrapolated estimate from an unpublished local survey, approximately 50,000 patients in Denmark are admitted each year for infections and treated with IV antibiotics. The average hospital stay for these patients is 5.9 days, resulting in a total of 295,000 hospital days annually, accounting for about 7% of total hospital admissions in Denmark. This represents an annual cost of 2.3 billion DKK. While some patients need hospitalization due to their overall health or other serious conditions, others remain hospitalized primarily to receive IV antibiotics. Expanding the use of oral antibiotics in emergency departments should be pursued only if it can demonstrate comparable efficacy and safety to IV administration. Therefore this study will investigate the efficiency of primarily oral antibiotics in acutely admitted patients with proven or suspected infections. Additionally, the investigators will evaluate the safety of oral regimen for these patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Suspected respiratory tract infection, urinary tract infection, or cellulitis by the attending physician

• Planned or initiated intravenous antibiotic treatment

Locations
Other Locations
Denmark
Sygehus Sønderjylland
RECRUITING
Aabenraa
Contact Information
Primary
Mariana Bichuette Cartuliares
mbc@rsyd.dk
+45 79971113
Backup
Helene Skjøt-Arkil
hsa@rsyd.dk
+45 79971113
Time Frame
Start Date: 2025-01-15
Estimated Completion Date: 2028-01-06
Participants
Target number of participants: 4000
Treatments
No_intervention: Standard Care
Standard intravenous treatment in accordance with local or national procedures
Active_comparator: Oral treatment
Oral treatment
Sponsors
Leads: University of Southern Denmark

This content was sourced from clinicaltrials.gov

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