• Male or Female, 18 years of age or older

• Subject has a medical diagnosis of venous leg ulcer or venous insufficiency with a lower extremity wound

• Subject has an venous leg ulcer without infection or clinically visible exposed bone

• Index wound is a minimum of 1 cm2 and a maximum of 30 cm2 at first treatment visit

• Adequate circulation if wound is location on the lower extremity demonstrated by an ABI of \>0.7 and \<1.3, or TBI of \>0.6 within 30 days prior to informed consent OR an arterial ultrasound noted with patent circulation and without significant stenosis 90 days prior to the first treatment visit.

• Venous Leg Ulcer is being treated with compression therapy for 7 days prior to treatment visit 1

• Index wound is free of necrotic debris prior to NeoThelium FT application

• Female subjects of childbearing potential having a negative pregnancy test prior to the first treatment visit

• Wound free of clinical signs/symptoms of infection (no purulent discharge or cellulitis) post-debridement during screening and prior to the first treatment visit.

⁃ Subject is able and willing to follow the protocol requirements

⁃ Subject had signed informed consent

⁃ If 2 or more wounds are present, the wounds must be separated by at least 2 cm