Find Venous Insufficiency Clinical Trials Near You
Evaluation of the Effects of Ruscus Aculeatus L. on Clinical Course and Quality of Life, and Assessment of Treatment Adherence and Tolerability in the Treatment of Chronic Venous Insufficiency: A Multicenter, Prospective, Observational Study
Status: Recruiting
Location: See all (25) locations...
Study Type: Observational
SUMMARY
This multicenter, prospective, observational study aims to generate and analyze real-world data on the effectiveness and safety of Ruscus aculeatus L. treatment in patients with symptomatic chronic venous disease classified as CEAP C1-C6. Patients receiving Ruscus aculeatus L. as part of routine clinical practice will be followed for 90 days without any study-mandated intervention. Disease severity will be assessed using the revised Venous Clinical Severity Score (rVCSS), pain using the Visual Analog Scale (VAS), quality of life using the Chronic Venous Disease Quality of Life Questionnaire (CIVIQ-20), treatment adherence using the Visual Analog Scale for adherence (VAS-U), and safety through the collection of adverse events during the observation period.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Adults aged 18 to 75 years.
• Patients prescribed Ruscus aculeatus L. as part of routine clinical practice, with the baseline visit performed within 7 days after treatment initiation.
• Symptomatic chronic venous disease classified as CEAP (2020) C1-C6.
• Willing and able to provide written informed consent and complete study as sessments.
Locations
Other Locations
Turkey
Ankara Training and Research Hospital
RECRUITING
Ankara
Ankara University Faculty of Medicine Hospital
RECRUITING
Ankara
Bilkent City Hospital
RECRUITING
Ankara
Etlik City Hospital
RECRUITING
Ankara
Gazi University Faculty of Medicine Hospital
NOT_YET_RECRUITING
Ankara
SBU Gulhane Training and Research Hospital
RECRUITING
Ankara
SBU Sincan Training and Research Hospital
RECRUITING
Ankara
Yıldırım Beyazıt University Yenimahalle Training and Research Hospital
RECRUITING
Ankara
Mustafa Kemal University Hospital
NOT_YET_RECRUITING
Antakya
Antalya City Hospital
RECRUITING
Antalya
Gaziantep University Faculty of Medicine Hospital
NOT_YET_RECRUITING
Gaziantep
Bagcilar Training and Research Hospital
RECRUITING
Istanbul
Bahcelievler State Hospital
RECRUITING
Istanbul
Bakırköy Sadi Konuk Eğitim Araştırma Hastanesi
NOT_YET_RECRUITING
Istanbul
Bezmiâlem Foundation University Hospital
RECRUITING
Istanbul
Kartal Dr. Lütfi Kırdar City Hospital
RECRUITING
Istanbul
Koşuyolu High Specialization Training and Research Hospital
RECRUITING
Istanbul
Prof. Dr. Cemil Taşcıoğlu City Hospital
NOT_YET_RECRUITING
Istanbul
SBÜ Şişli Hamidiye Etfal Training and Research Hospital
RECRUITING
Istanbul
Bakırçay Üniversitesi Çiğli Eğitim ve Araştırma Hastanesi
RECRUITING
Izmir
Ege University Faculty of Medicine Hospital
RECRUITING
Izmir
Kahramanmaraş Sütçü İmam University Faculty of Medicine
RECRUITING
Kahramanmaraş
Necmettin Erbakan University Meram Faculty of Medicine Hospital
RECRUITING
Konya
Inonu University Turgut Ozal Medical Center
RECRUITING
Malatya
Sivas Cumhuriyet University Faculty of Medicine Research and Application Hospital
RECRUITING
Sivas
Contact Information
Primary
Nevzat Erdil, MD
nevzatkutay@gmail.com
+90 532 427 18 20
Time Frame
Start Date:2026-06-02
Estimated Completion Date:2027-06-01
Participants
Target number of participants:564
Treatments
Patients with Symptomatic Chronic Venous Disease Receiving Ruscus aculeatus L.
Adults with symptomatic chronic venous disease (CEAP C1-C6) who are prescribed Ruscus aculeatus L. as part of routine clinical practice. Participants will be followed prospectively for approximately 90 days without any study-specific intervention. Clinical outcomes, treatment adherence, quality of life, and safety data will be collected during routine clinical visits at baseline, Day 30, and Day 90.