A Study of Initiation Timing of VTE Prevention After Colorectal Cancer Surgery: a Single-center, Prospective, Observational Cohort Study

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY

This project intends to conduct a single-center, prospective, observational cohort study to explore the impact of the timing of drug prophylaxis on the risk of postoperative bleeding and the preventive effect of VTE in the prevention and management of postoperative venous thromboembolism (VTE) after colorectal cancer (CRC) surgery in Chinese population, and to determine its application and promotion value. The research results of this project can provide useful reference for optimizing the prevention and management of VTE after CRC operation.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 110
Healthy Volunteers: f
View:

• ① Age \> 18 years old;

• ② The patient was diagnosed with colorectal cancer, and the cTMN stage was cT1-2, N0 or cT3, N0 or any cT, N1-2; (3) The patient was diagnosed with colorectal cancer and was able to receive radical surgery (laparoscopic or open surgery). The expected operation time was \>45 minutes, and the expected postoperative survival time was \>6 months.

• ④ The patient or guardian agrees to the study plan and signs the informed consent.

Locations
Other Locations
China
Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine
RECRUITING
Shanghai
Contact Information
Primary
Meng Hu, PhD
humeng@renji.com
+8615000090636
Time Frame
Start Date: 2024-02-01
Estimated Completion Date: 2025-06-01
Participants
Target number of participants: 914
Treatments
Early initiation of drug prophylaxis (within 24 hours after surgery)
Patients who underwent surgery received prophylactic administration of low molecular weight heparin (nardraparin calcium injection) at a time point of 24 hours after surgery,this group carries out early initiation of drug prophylaxis (within 24 hours after surgery)
Late initiation of drug prophylaxis (24 hours after surgery)
Patients who underwent surgery received prophylactic administration of low molecular weight heparin (nardraparin calcium injection) at a time point of 24 hours after surgery,this group carries out late initiation of drug prophylaxis ( 24 hours after surgery)
Sponsors
Leads: RenJi Hospital

This content was sourced from clinicaltrials.gov