Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: f
View:

• Active duty military

• 18-55 years old

• Over 6 months remaining at local duty station

Locations
United States
Washington
Madigan Army Medical Center
RECRUITING
Tacoma
Contact Information
Primary
Kevin D Smith, DMD
kevin.d.smith2.mil@health.mil
253-968-0181
Backup
Zachary T Colburn, PhD
zachary.t.colburn.civ@health.mil
253-968-3455
Time Frame
Start Date: 2022-07-28
Estimated Completion Date: 2025-11
Participants
Target number of participants: 150
Treatments
No_intervention: Control
This arm will receive standard of care during dental implant insertion.
Experimental: Chlorhexidine
Chlorhexidine treatment.
Experimental: Hydrogen Peroxide
Hydrogen Peroxide treatment.
Related Therapeutic Areas
Sponsors
Collaborators: United States Department of Defense
Leads: Madigan Army Medical Center

This content was sourced from clinicaltrials.gov