Efficacy of Montelukast in Preventing Transaminase Elevation in Adult Dengue Patients: a Randomized, Double-blind, Placebo Controlled, Superiority Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
The goal of this clinical trial is to learn if drug montelukast works to treat dengue in adults. It will also learn about the safety of drug montelukast . The main questions it aims to answer are: Does drug montelukast lower the incidence of liver enzyme elevations in participants ? What medical problems do participants have when taking drug montelukast ?
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Healthy Volunteers: f
View:
• Patient age \>18 years
• Dengue infection diagnosed by NS1 antigen, or polymerase chain reaction
• Admitted to the hospital
• Written informed consent from patient or attending relative able to and willing to give informed consent
Locations
Other Locations
Thailand
Phramongkutklao Hospital
RECRUITING
Bangkok
Contact Information
Primary
Vasin Vasikasin, MD PhD
vvasin@gmail.com
66+027639300
Backup
Kotchaphon Waithayakul, MD
nasomsong.w@gmail.com
66+027639300
Time Frame
Start Date: 2025-01-31
Estimated Completion Date: 2027-01
Participants
Target number of participants: 82
Treatments
Experimental: Montelukast
a 10 mg tablet will be given orally immediately and every day thereafter for 10 days or until recovery, defined as the discontinuation of the follow up appointment by the attending physicians, whichever is shorter
Placebo_comparator: Placebo
a 10 mg tablet will be given orally immediately and every day thereafter for 10 days or until recovery, defined as the discontinuation of the follow up appointment by the attending physicians, whichever is shorter
Related Therapeutic Areas
Sponsors
Leads: Phramongkutklao College of Medicine and Hospital