EFFECTIVENESS OF COMBINING MICRO NEEDLING WITH 5 FLUOROURACIL VERSUS POTENT TOPICAL STEROIDS; IN TREATING LIMITED VITILIGO-RANDOMIZED CONTROLLED STUDY

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin. It will also learn about the safety of both these treatments. The main questions it aims to answer are: * How well does 5FU with microneedling work to treat vitiligo by returning pigmentation in vitiligo patches as compared to steroid? * What is participant's satisfaction when treated with 5FU with microneedling as compared to steroid? * What skin problems do participants have when treated with FU with microneedling and steroid? Researchers will compare 5FU with microneedling to steroid application to see how well both work to return pigment in vitiligo patches. Participants will be divided into two groups. For Group A, 5 FU will be rubbed and absorbed on the vitiligo patch after micro-needling every 2 weeks. For group B, topical 0.05% clobetasol propionate ointment will be applied twice a day on the vitiligo patches for 12 weeks. Vitiligo patches will be assessed at the start of trial and then after 12 weeks of treatment.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 4
Maximum Age: 70
Healthy Volunteers: f
View:

• Patients willing to participate in the study

• Patients of age group of 05 -70 years.

• Vitiligo involving less than or equal to 10% body surface area.

Locations
Other Locations
Pakistan
CMH Bahawalpur
RECRUITING
Chak Four Hundred Fifty-four
Time Frame
Start Date: 2025-08-08
Estimated Completion Date: 2026-02
Participants
Target number of participants: 40
Treatments
Experimental: Microneedling with topical 5-fluorouracil
Active_comparator: Clobetasol propionate 0.05%
Related Therapeutic Areas
Sponsors
Leads: Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan

This content was sourced from clinicaltrials.gov