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Intralesional Therapies For Cutaneous Viral Warts: A Comparative Analysis Of Vitamin D3 And Acyclovir

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The goal of this clinical trial is to learn if injecting acyclovir (an antiviral drug) or vitamin D3 directly into skin warts works to clear them in people aged 12 and older with common, plantar, flat, or periungual (around the nail) warts. The main questions it aims to answer are: 1. Does intralesional acyclovir or vitamin D3 lead to complete clearance of warts by week 8? 2. Which treatment clears warts more effectively? 3. What side effects do participants have with each treatment? Researchers will compare acyclovir injections (Group A) to vitamin D3 injections (Group B), with 20 participants in each group, to see which treatment works better at clearing warts. Participants will: 1. Receive an injection directly into the wart every 2 weeks for up to 4 sessions 2. Have photographs taken of their warts before treatment and at each visit 3. Visit the clinic for checkups where the size and number of warts will be measured 4. Be followed for up to 3 months to check for wart recurrence and side effects

Eligibility
Participation Requirements
Sex: All
Minimum Age: 12
Healthy Volunteers: f
View:

• Patients aged 12 years and above with clinically diagnosed cutaneous warts

• Common, plantar, flat, or periungual warts

• Both treatment-naïve patients and those with recalcitrant warts

Locations
Other Locations
Pakistan
Riphah International Hospital, Islamabad Expy, Sector A DHA Phase 5, Islamabad
RECRUITING
Islamabad
Railway General Hospital, Railway Carriage Factory Rd, Railway Scheme 7, Rawalpindi
RECRUITING
Rawalpindi
Time Frame
Start Date: 2026-02-20
Estimated Completion Date: 2026-05-20
Participants
Target number of participants: 40
Treatments
Experimental: Intralesional Acyclovir
Participants receive intralesional injection of acyclovir. Injections are administered at baseline and repeated every 2 weeks for a maximum of four sessions.
Active_comparator: Intralesional Vitamin D3
Participants receive intralesional injection of vitamin D3 (200,000 IU). Injections are administered at baseline and repeated every 2 weeks for a maximum of four sessions.
Related Therapeutic Areas
Sponsors
Leads: Riphah International University

This content was sourced from clinicaltrials.gov

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