Learn About Wolf-Hirschhorn Syndrome

What is the definition of Wolf-Hirschhorn Syndrome?

Wolf-Hirschhorn syndrome is a condition that affects many parts of the body. The major features of this disorder include a characteristic facial appearance, delayed growth and development, intellectual disability, and seizures.

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What are the causes of Wolf-Hirschhorn Syndrome?

Wolf-Hirschhorn syndrome is caused by a deletion of genetic material near the end of the short (p) arm of chromosome 4. This chromosomal change is sometimes written as 4p-. The size of the deletion varies among affected individuals; studies suggest that larger deletions tend to result in more severe intellectual disability and physical abnormalities than smaller deletions.

How prevalent is Wolf-Hirschhorn Syndrome?

The prevalence of Wolf-Hirschhorn syndrome is estimated to be 1 in 50,000 births. However, this may be an underestimate because it is likely that some affected individuals are never diagnosed.

Is Wolf-Hirschhorn Syndrome an inherited disorder?

Between 85 and 90 percent of all cases of Wolf-Hirschhorn syndrome are not inherited. They result from a chromosomal deletion that occurs as a random (de novo) event during the formation of reproductive cells (eggs or sperm) or in early embryonic development. More complex chromosomal rearrangements can also occur as de novo events, which may help explain the variability in the condition's signs and symptoms. De novo chromosomal changes occur in people with no history of the disorder in their family.

Who are the top Wolf-Hirschhorn Syndrome Local Doctors?
Elite
Highly rated in
12
conditions

University Of Bern

Pisa, IT 

Agatino Battaglia is in Pisa, Italy. Battaglia is rated as an Elite expert by MediFind in the treatment of Wolf-Hirschhorn Syndrome. They are also highly rated in 12 other conditions, according to our data. Their top areas of expertise are Wolf-Hirschhorn Syndrome, Filippi Syndrome, Early Infantile Epileptic Encephalopathy, and Hypotonia.

Elite
Highly rated in
29
conditions

Università Cattolica Del Sacro Cuore

Rome, IT 

Marcella Zollino is in Rome, Italy. Zollino is rated as an Elite expert by MediFind in the treatment of Wolf-Hirschhorn Syndrome. She is also highly rated in 29 other conditions, according to our data. Her top areas of expertise are Wolf-Hirschhorn Syndrome, Ring Chromosome 14, Pitt-Hopkins Syndrome, and Smith-Magenis Syndrome.

 
 
 
 
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Distinguished
Highly rated in
2
conditions

Hospital Universitario Central De Asturias

Neurophysiology Department 
Oviedo, AS, ES 

Raquel Lago-Blanco is in Oviedo, Spain. Lago-Blanco is rated as a Distinguished expert by MediFind in the treatment of Wolf-Hirschhorn Syndrome. She is also highly rated in 2 other conditions, according to our data. Her top areas of expertise are Wolf-Hirschhorn Syndrome, Glucose Transporter Deficiency, Epilepsy in Children, and Intrauterine Growth Restriction.

What are the latest Wolf-Hirschhorn Syndrome Clinical Trials?
An Open-Label Study of the Safety, Tolerability, and Pharmacokinetics of Oral NNZ-2591 in Pitt Hopkins Syndrome (PTHS-001)
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Coordination of Rare Diseases at Sanford
Who are the sources who wrote this article ?

Published Date:updated Last, April

Published By: National Institutes of Health

What are the Latest Advances for Wolf-Hirschhorn Syndrome?

There is no recent research available for this condition. Please check back because thousands of new papers are published every week and we strive to find and display the most recent relevant research as soon as it is available.