Abdolkarim Farrokhzadeh
Cape Town, WC 7700, South Africa
Last Updated: 09/26/2026
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Found 13 publications
Deciphering the Mechanism of Binding Selectivity of Chlorofluoroacetamide-Based Covalent Inhibitors toward L858R/T790M Resistance Mutation.
Journal: Journal of chemical information and modeling
Published: February 04, 2022
Molecular Mechanism Exploration of Potent Fluorinated PI3K Inhibitors with a Triazine Scaffold: Unveiling the Unusual Synergistic Effect of Pyridine-to-Pyrimidine Ring Interconversion and CF3 Defluorination.
Journal: The journal of physical chemistry. B
Published: September 02, 2021
Mechanistic Study of Potent Fluorinated EGFR Kinase Inhibitors with a Quinazoline Scaffold against L858R/T790M/C797S Resistance Mutation: Unveiling the Fluorine Substituent Cooperativity Effect on the Inhibitory Activity.
Journal: The journal of physical chemistry. B
Published: July 01, 2020
Impact of HEC72702 chirality on the selective inhibition of hepatitis B virus capsid dimer: A dynamics-structure-energetics perspective.
Journal: Chemical biology & drug design
Published: May 29, 2020
A Mechanistic Study of a Potent and Selective Epidermal Growth Factor Receptor Inhibitor against the L858R/T790M Resistance Mutation.
Journal: Biochemistry
Published: October 08, 2019
Revealing the distinct mechanistic binding and activity of 5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazole enantiomers against FGFR1.
Journal: Physical chemistry chemical physics : PCCP
Published: June 27, 2019
The irony of chirality - unveiling the distinct mechanistic binding and activities of 1-(3-(4-amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidin-1-yl)prop-2-en-1-one enantiomers as irreversible covalent FGFR4 inhibitors.
Journal: Organic & biomolecular chemistry
Published: January 16, 2019
Covalent vs. Non-Covalent Inhibition: Tackling Drug Resistance in EGFR - A Thorough Dynamic Perspective.
Journal: Chemistry & biodiversity
Published: October 02, 2018
Noteworthy effect of slight variation in aliphatic chain length of trisubstituted imidazole inhibitors against epidermal growth factor receptor L858R/T790M/C797S mutant in cancer therapy.
Journal: Chemical biology & drug design
Published: September 07, 2018
Probing the Dynamic Mechanism of Uncommon Allosteric Inhibitors Optimized to Enhance Drug Selectivity of SHP2 with Therapeutic Potential for Cancer Treatment.
Journal: Applied biochemistry and biotechnology
Published: July 18, 2018
A theoretical study of π-stacking interactions in C-substituted tetrazoles.
Journal: Journal of molecular graphics & modelling
Published: February 28, 2016
Last Updated: 09/26/2026