Last Updated: 09/26/2026
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Found 2 publications
AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells.
Journal: Cell reports
Published: August 22, 2022
AKT Degradation Selectively Inhibits the Growth of PI3K/PTEN Pathway-Mutant Cancers with Wild-Type KRAS and BRAF by Destabilizing Aurora Kinase B.
Journal: Cancer discovery
Published: June 12, 2020
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Last Updated: 09/26/2026