Achim J. Doerner

Merck Healthcare KGaA, Frankfurter Str. 250
Darmstadt, HE 64293, Germany

Last Updated: 09/26/2026

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Found 29 publications

Generation and Characterization of Bispecific VHH-Derived Surrogate Agonists Mimicking the Function of IL-18.

Generation and Characterization of Bispecific VHH-Derived Surrogate Agonists Mimicking the Function of IL-18.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: May 13, 2026

A Rational Design Strategy for Engineering CH4 Domain of IgE for Heterodimerization.

A Rational Design Strategy for Engineering CH4 Domain of IgE for Heterodimerization.

Journal: Biotechnology and bioengineering

Published: April 04, 2025

IgE based therapeutics are an emerging modality in cancer treatment.

IgE based therapeutics are an emerging modality in cancer treatment.

Journal: Discover oncology

Published: November 18, 2024

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities.

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities.

Journal: Protein science : a publication of the Protein Society

Published: October 22, 2024

Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects.

Advancements in mammalian display technology for therapeutic antibody development and beyond: current landscape, challenges, and future prospects.

Journal: Frontiers in immunology

Published: July 23, 2024

Systematic mutational analysis reveals an essential role of N275 in IgE stability.

Systematic mutational analysis reveals an essential role of N275 in IgE stability.

Journal: Biotechnology and bioengineering

Published: February 03, 2024

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody-drug conjugates targeting c-MET.

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody-drug conjugates targeting c-MET.

Journal: mAbs

Published: January 12, 2024

Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.

Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.

Journal: Biological chemistry

Published: December 14, 2023

A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates.

A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates.

Journal: International journal of molecular sciences

Published: November 20, 2023

Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening.

Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening.

Journal: mAbs

Published: August 30, 2023

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.

Journal: mAbs

Published: July 20, 2023

Antibody-Secreting Cell Isolation from Different Species for Microfluidic Antibody Hit Discovery.

Antibody-Secreting Cell Isolation from Different Species for Microfluidic Antibody Hit Discovery.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: July 05, 2023

Showing 1-12 of 29

Last Updated: 09/26/2026