Adele M. Lehane

Linnaeus Way
Acton, ACT 2601, Australia

Last Updated: 09/26/2026

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Found 40 publications

Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na+ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening.

Identification of α-Azacyclic Acetamide-Based Inhibitors of P. falciparum Na+ Pump (PfATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening.

Journal: ACS infectious diseases

Published: September 08, 2025

Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter.

Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter.

Journal: ChemMedChem

Published: August 29, 2025

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na + pump ( Pf ATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening.

Identification of α-azacyclic acetamide-based inhibitors of P. falciparum Na + pump ( Pf ATP4) with fast-killing asexual blood-stage antimalarial activity by phenotypic screening.

Journal: bioRxiv : the preprint server for biology

Published: June 06, 2025

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.

Journal: Journal of medicinal chemistry

Published: April 14, 2025

PfATP2 is a flippase on the Plasmodium falciparum surface that is important for growth and influences parasite sensitivity to antiplasmodial compounds.

PfATP2 is a flippase on the Plasmodium falciparum surface that is important for growth and influences parasite sensitivity to antiplasmodial compounds.

Journal: PLoS pathogens

Published: February 11, 2025

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.

Journal: Journal of medicinal chemistry

Published: August 12, 2024

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4.

Journal: ChemMedChem

Published: July 18, 2024

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3.

Journal: European journal of medicinal chemistry

Published: June 13, 2024

A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets.

A pH Fingerprint Assay to Identify Inhibitors of Multiple Validated and Potential Antimalarial Drug Targets.

Journal: ACS infectious diseases

Published: March 18, 2024

Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides.

Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides.

Journal: International journal for parasitology. Drugs and drug resistance

Published: June 01, 2023

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.

Journal: Journal of medicinal chemistry

Published: February 22, 2023

A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.

A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.

Journal: Nature communications

Published: June 26, 2022

Showing 1-12 of 40

Last Updated: 09/26/2026