Adrian M. Isaacs

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 94 publications

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation.

Journal: bioRxiv : the preprint server for biology
Published: August 01, 2026

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.

Scalable human neuronal models of tauopathy producing endogenous seed-competent 4R tau.

Journal: Science advances
Published: July 31, 2026

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis.

U7 small nuclear RNA splice-switching therapeutics for STMN2 and UNC13A in Amyotrophic Lateral Sclerosis.

Journal: bioRxiv : the preprint server for biology
Published: December 15, 2025

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.

Generation of C9orf72 repeat knock-in iPSC lines for modelling ALS and FTD.

Journal: bioRxiv : the preprint server for biology
Published: October 01, 2025

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS.

An alternative cytoplasmic SFPQ isoform with reduced phase separation potential is up-regulated in ALS.

Journal: Science advances
Published: August 22, 2025

C9orf72 poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia.

C9orf72 poly(glycine-alanine) knock-in mice exhibit mild rotarod and proteomic changes consistent with amyotrophic lateral sclerosis/frontotemporal dementia.

Journal: Brain communications
Published: June 12, 2025

CTAD taskforce: genetic therapies in Alzheimer's disease.

CTAD taskforce: genetic therapies in Alzheimer's disease.

Journal: The journal of prevention of Alzheimer's disease
Published: April 17, 2025

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Journal: Developmental cell
Published: March 10, 2025

Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD.

Author Correction: Neuronal polyunsaturated fatty acids are protective in ALS/FTD.

Journal: Nature neuroscience
Published: March 07, 2025

Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.

Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis.

Journal: Disease models & mechanisms
Published: February 18, 2025

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation.

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1-induced endoplasmic reticulum-associated degradation.

Journal: Cell reports
Published: October 23, 2024

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids.

Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids.

Journal: Acta neuropathologica communications
Published: August 21, 2024
Showing 1-12 of 94

Last Updated: 09/26/2026