Ahmed M. Saghier-El

Sohag University 282524 Sohag Egypt
Sohag, SHG 28252, Egypt

Last Updated: 09/26/2026

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Found 26 publications

Design, synthesis, and anti-fibrotic evaluation of novel sulfonamide-embedded 1,2,4-triazinone derivatives in TGF-β-activated hepatic stellate cells (LX-2).

Design, synthesis, and anti-fibrotic evaluation of novel sulfonamide-embedded 1,2,4-triazinone derivatives in TGF-β-activated hepatic stellate cells (LX-2).

Journal: RSC medicinal chemistry

Published: April 15, 2026

Novel N-4-(5-Amino-7-substituted-triazolotriazinepiperazin-1-yl) Norfloxacin Analogues Exhibit Potent and Selective Anticancer Activity via Topoisomerase Inhibition, Cell-Cycle Arrest, and Apoptosis in A 431 Skin Carcinoma Cells.

Novel N-4-(5-Amino-7-substituted-triazolotriazinepiperazin-1-yl) Norfloxacin Analogues Exhibit Potent and Selective Anticancer Activity via Topoisomerase Inhibition, Cell-Cycle Arrest, and Apoptosis in A 431 Skin Carcinoma Cells.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: March 25, 2026

Design, synthesis, and biological evaluation of novel Spirosulfamethoxazole-1,3,4-thiadiazole-2-carboxamide derivatives as dual COX-2/5-LOX inhibitors with promising anti-inflammatory and anti-osteoarthritic potential.

Design, synthesis, and biological evaluation of novel Spirosulfamethoxazole-1,3,4-thiadiazole-2-carboxamide derivatives as dual COX-2/5-LOX inhibitors with promising anti-inflammatory and anti-osteoarthritic potential.

Journal: Bioorganic chemistry

Published: February 21, 2026

Newly Designed 3d-Metal(II) Complexes From Thiadiazole-Carboxamide Ligand With Potential Antimicrobial, Anticancer, and DNA-Reactivity.

Newly Designed 3d-Metal(II) Complexes From Thiadiazole-Carboxamide Ligand With Potential Antimicrobial, Anticancer, and DNA-Reactivity.

Journal: Journal of biochemical and molecular toxicology

Published: November 04, 2025

Synthesis, characterization, molecular docking and in vitro anti-arthritic activity of some novel spiro [1,3,4] thiadiazole derivatives based on thioxoacetamides.

Synthesis, characterization, molecular docking and in vitro anti-arthritic activity of some novel spiro [1,3,4] thiadiazole derivatives based on thioxoacetamides.

Journal: BMC chemistry

Published: October 23, 2025

Novel Benzenesulfonamide Derivatives of 5'-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema.

Novel Benzenesulfonamide Derivatives of 5'-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema.

Journal: Biomedicines

Published: June 08, 2025

Design, Synthesis, and In Silico Studies of New Norfloxacin Analogues with Broad Spectrum Antibacterial Activity via Topoisomerase II Inhibition.

Design, Synthesis, and In Silico Studies of New Norfloxacin Analogues with Broad Spectrum Antibacterial Activity via Topoisomerase II Inhibition.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: March 07, 2025

Functionalized Thiadiazole: Synthesis, insecticidal activity, molecular docking and DFT studies of some new 5-substituted 1,2,4-Thiadiazoles based on Norfloxacin.

Functionalized Thiadiazole: Synthesis, insecticidal activity, molecular docking and DFT studies of some new 5-substituted 1,2,4-Thiadiazoles based on Norfloxacin.

Journal: Bioorganic chemistry

Published: February 21, 2025

Design, Synthesis, Anticancer Screening, and Mechanistic Study of Spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide Derivatives.

Design, Synthesis, Anticancer Screening, and Mechanistic Study of Spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide Derivatives.

Journal: International journal of molecular sciences

Published: November 13, 2024

Correction: Synthesis, docking and biological evaluation of purine-5-N-isosteres as anti-inflammatory agents.

Correction: Synthesis, docking and biological evaluation of purine-5-N-isosteres as anti-inflammatory agents.

Journal: RSC advances

Published: June 24, 2024

Thiadiazole/Thiadiazine Derivatives as Insecticidal Agent: Design, Synthesis, and Biological Assessment of 1,3,4-(Thiadiazine/Thiadiazole)-Benzenesulfonamide Derivatives as IGRs Analogues against Spodoptera littoralis.

Thiadiazole/Thiadiazine Derivatives as Insecticidal Agent: Design, Synthesis, and Biological Assessment of 1,3,4-(Thiadiazine/Thiadiazole)-Benzenesulfonamide Derivatives as IGRs Analogues against Spodoptera littoralis.

Journal: Journal of agricultural and food chemistry

Published: May 10, 2024

Synthesis, docking and biological evaluation of purine-5-N-isosteresas anti-inflammatory agents.

Synthesis, docking and biological evaluation of purine-5-N-isosteresas anti-inflammatory agents.

Journal: RSC advances

Published: April 22, 2024

Showing 1-12 of 26

Last Updated: 09/26/2026