Ai Takano

Tokyo, Japan

Last Updated: 09/26/2026

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Found 12 publications

Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma.

Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma.

Journal: Nature cell biology
Published: October 12, 2022

Identification of Quiescent LGR5+ Stem Cells in the Human Colon.

Identification of Quiescent LGR5+ Stem Cells in the Human Colon.

Journal: Gastroenterology
Published: October 13, 2021

Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.

Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer.

Journal: Nature chemical biology
Published: March 03, 2021

Cell-matrix interface regulates dormancy in human colon cancer stem cells.

Cell-matrix interface regulates dormancy in human colon cancer stem cells.

Journal: Nature
Published: December 15, 2020

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping.

Journal: Cell
Published: December 30, 2019

Somatic inflammatory gene mutations in human ulcerative colitis epithelium.

Somatic inflammatory gene mutations in human ulcerative colitis epithelium.

Journal: Nature
Published: February 27, 2019

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition.

Journal: Cell stem cell
Published: September 04, 2018

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.

Journal: Cell
Published: March 23, 2018

Visualization and targeting of LGR5+ human colon cancer stem cells.

Visualization and targeting of LGR5+ human colon cancer stem cells.

Journal: Nature
Published: June 21, 2016

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.

Journal: Cell stem cell
Published: November 11, 2015

A novel Bunyavirus from the soft tick, Argas vespertilionis, in Japan.

A novel Bunyavirus from the soft tick, Argas vespertilionis, in Japan.

Journal: The Journal of veterinary medical science
Published: October 27, 2015

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

Journal: Nature medicine
Published: June 27, 2014
Showing 1-12 of 12

Last Updated: 09/26/2026