Akihiro Tomida

Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.

Journal: Biochemical and biophysical research communications

Published: July 27, 2026

HER3 enhances ATF4 induction and survival in breast cancer cells during endoplasmic reticulum stress.

Journal: Biochemical and biophysical research communications

Published: December 23, 2025

Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity.

Journal: Cancer science

Published: March 12, 2024

Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma.

Journal: Journal of cellular biochemistry

Published: October 20, 2023

Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation.

Journal: Heliyon

Published: February 05, 2023

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation.

Journal: Scientific reports

Published: March 01, 2022

eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.

Journal: Biochemical and biophysical research communications

Published: August 05, 2021

Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.

Journal: Cancer science

Published: October 29, 2020

GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.

Journal: Molecular pharmacology

Published: May 14, 2020

Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy.

Journal: iScience

Published: September 11, 2019

The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.

Journal: The Journal of biological chemistry

Published: August 14, 2019

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.

Journal: Biochemical and biophysical research communications

Published: August 31, 2018

Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.

Pharmacological blockade of oncogenic MAPK activators drives resistance to cystine deprivation with lipid redox remodeling.

HER3 enhances ATF4 induction and survival in breast cancer cells during endoplasmic reticulum stress.

HER3 enhances ATF4 induction and survival in breast cancer cells during endoplasmic reticulum stress.

Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity.

Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity.

Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma.

Induction of stearoyl-CoA desaturase confers cell density-dependent ferroptosis resistance in melanoma.

Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation.

Activating mutations in EGFR and PI3K promote ATF4 induction for NSCLC cell survival during amino acid deprivation.

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation.

Spautin-1 inhibits mitochondrial complex I and leads to suppression of the unfolded protein response and cell survival during glucose starvation.

eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.

eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.

Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.

Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.

GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.

GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.

Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy.

Disrupting ATF4 Expression Mechanisms Provides an Effective Strategy for BRAF-Targeted Melanoma Therapy.

The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.

The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.

BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.