Akiko Itai

Tokyo, 1130033, Japan

Last Updated: 09/26/2026

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Found 21 publications

Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure.

Design, Synthesis, and Anti-Inflammatory Evaluation of a Novel PPARδ Agonist with a 4-(1-Pyrrolidinyl)piperidine Structure.

Journal: Journal of medicinal chemistry

Published: August 08, 2023

Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists.

Discovery and structure-activity relationship study of 2-piperazinyl-benzothiazole derivatives as potent and selective PPARδ agonists.

Journal: Bioorganic & medicinal chemistry

Published: January 15, 2023

Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method.

Discovery and structure-based design of a new series of potent and selective PPARδ agonists utilizing a virtual screening method.

Journal: Bioorganic & medicinal chemistry letters

Published: November 24, 2021

Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354.

Attenuation of experimental autoimmune uveoretinitis in mice by IKKβ inhibitor IMD-0354.

Journal: Biochemical and biophysical research communications

Published: February 04, 2020

IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice.

IKKβ Inhibitor IMD-0354 Attenuates Radiation Damage in Whole-body X-Irradiated Mice.

Journal: Oxidative medicine and cellular longevity

Published: January 28, 2019

A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice.

A novel IkB kinase inhibitor attenuates ligature-induced periodontal disease in mice.

Journal: Journal of periodontal research

Published: September 14, 2017

Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination.

Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination.

Journal: Oncotarget

Published: November 23, 2016

The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice.

The Novel IκB Kinase β Inhibitor, IMD-0560, Has Potent Therapeutic Efficacy in Ovarian Cancer Xenograft Model Mice.

Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

Published: February 25, 2016

Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells.

Targeting Inhibitor of κB Kinase β Prevents Inflammation-Induced Preterm Delivery by Inhibiting IL-6 Production from Amniotic Cells.

Journal: The American journal of pathology

Published: June 26, 2015

IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators.

IMD-4690, a novel specific inhibitor for plasminogen activator inhibitor-1, reduces allergic airway remodeling in a mouse model of chronic asthma via regulating angiogenesis and remodeling-related mediators.

Journal: PloS one

Published: October 21, 2014

The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma.

The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma.

Journal: Oncotarget

Published: September 16, 2014

IκB kinase-β inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice.

IκB kinase-β inhibitor IMD-0354 beneficially suppresses retinal vascular permeability in streptozotocin-induced diabetic mice.

Journal: Investigative ophthalmology & visual science

Published: September 11, 2014

Showing 1-12 of 21

Last Updated: 09/26/2026