Alastair H. Kyle

Vancouver, BC, Canada

Last Updated: 09/26/2026

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Found 26 publications

Accumulation of liposomes in metastatic tumor sites is not necessary for anti-cancer drug efficacy.

Accumulation of liposomes in metastatic tumor sites is not necessary for anti-cancer drug efficacy.

Journal: Journal of translational medicine

Published: February 27, 2024

A Flexible Semi-automated Assay for Assessing Radiation-sensitization and Toxicity in the Mouse Intestine.

A Flexible Semi-automated Assay for Assessing Radiation-sensitization and Toxicity in the Mouse Intestine.

Journal: Anticancer research

Published: February 27, 2024

DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors.

DNA-PK inhibitor AZD7648 is a more portent radiosensitizer than PARP inhibitor Olaparib in BRCA1/2 deficient tumors.

Journal: DNA repair

Published: January 25, 2024

Detection of FLASH-radiotherapy tissue sparing in a 3D-spheroid model using DNA damage response markers.

Detection of FLASH-radiotherapy tissue sparing in a 3D-spheroid model using DNA damage response markers.

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Published: November 20, 2023

Radiation and Chemo-Sensitizing Effects of DNA-PK Inhibitors Are Proportional in Tumors and Normal Tissues.

Radiation and Chemo-Sensitizing Effects of DNA-PK Inhibitors Are Proportional in Tumors and Normal Tissues.

Journal: Molecular cancer therapeutics

Published: October 04, 2023

DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost.

DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost.

Journal: Scientific reports

Published: May 09, 2023

Radiosensitizing oxygenation changes in murine tumors treated with VEGF-ablation therapy are measurable using oxygen enhanced-MRI (OE-MRI).

Radiosensitizing oxygenation changes in murine tumors treated with VEGF-ablation therapy are measurable using oxygen enhanced-MRI (OE-MRI).

Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Published: May 08, 2023

Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model.

Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model.

Journal: International journal of molecular sciences

Published: March 24, 2021

Dosimetry with a clinical linac adapted to FLASH electron beams.

Dosimetry with a clinical linac adapted to FLASH electron beams.

Journal: Journal of applied clinical medical physics

Published: February 27, 2020

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically.

Journal: Cancer immunology research

Published: November 02, 2018

Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment.

Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment.

Journal: Clinical & experimental metastasis

Published: May 07, 2018

The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth.

The differential effects of metronomic gemcitabine and antiangiogenic treatment in patient-derived xenografts of pancreatic cancer: treatment effects on metabolism, vascular function, cell proliferation, and tumor growth.

Journal: Angiogenesis

Published: February 05, 2016

Showing 1-12 of 26

Last Updated: 09/26/2026