Alejandra C. Tomas

London, ENG W120NN, United Kingdom

Last Updated: 09/26/2026

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Found 73 publications

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment.

Glycemic and bodyweight effects of GIPR coding variation reflect differences in surface expression and intrinsic functional impairment.

Journal: Science advances

Published: September 04, 2026

In vivo functional profiling and structural characterization of the human GLP1R A316T variant.

In vivo functional profiling and structural characterization of the human GLP1R A316T variant.

Journal: Science advances

Published: February 04, 2026

Signaling architecture of the glucagon-like peptide-1 receptor.

Signaling architecture of the glucagon-like peptide-1 receptor.

Journal: The Journal of clinical investigation

Published: January 16, 2026

Editorial: The impact of GIP/GIPR on metabolic diseases: how the field is evolving.

Editorial: The impact of GIP/GIPR on metabolic diseases: how the field is evolving.

Journal: Frontiers in endocrinology

Published: September 22, 2025

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.

GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function.

Journal: bioRxiv : the preprint server for biology

Published: August 12, 2025

Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.

Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.

Journal: Molecular metabolism

Published: July 30, 2025

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells.

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells.

Journal: eLife

Published: April 24, 2025

Therapeutic potential of basil (Ocimum basilicum L.) aqueous extract: Impact on glycemia and oxidative stress in normoglycemic and diabetic rats.

Therapeutic potential of basil (Ocimum basilicum L.) aqueous extract: Impact on glycemia and oxidative stress in normoglycemic and diabetic rats.

Journal: Die Pharmazie

Published: April 10, 2025

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001.

Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001.

Journal: bioRxiv : the preprint server for biology

Published: January 27, 2025

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001.

Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel GLP-1R/GIPR dual agonist, HISHS-2001.

Journal: Diabetes, obesity & metabolism

Published: January 17, 2025

Oppositely biased glucagon-like peptide-1 receptor agonism does not differentially affect lipid metabolism in APOE*3-Leiden CETP mice.

Oppositely biased glucagon-like peptide-1 receptor agonism does not differentially affect lipid metabolism in APOE*3-Leiden CETP mice.

Journal: Diabetes, obesity & metabolism

Published: January 16, 2025

Human class B1 GPCR modulation by plasma membrane lipids.

Human class B1 GPCR modulation by plasma membrane lipids.

Journal: Communications biology

Published: January 12, 2025

Showing 1-12 of 73

Last Updated: 09/26/2026