Alessandra Bigi

Florence, 50134, Italy

Last Updated: 09/26/2026

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Found 33 publications

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.

Journal: Journal of medicinal chemistry

Published: May 27, 2026

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome-linked mutations.

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome-linked mutations.

Journal: The FEBS journal

Published: July 03, 2025

Human astrocytes from healthy individuals and Alzheimer's patients respond differently to Aβ1-42 oligomers, triggering distinct paths of reactivity and senescence.

Human astrocytes from healthy individuals and Alzheimer's patients respond differently to Aβ1-42 oligomers, triggering distinct paths of reactivity and senescence.

Journal: Mechanisms of ageing and development

Published: June 26, 2025

Engineering a dimeric single-domain antibody for improved detection and neutralization of amyloid-β oligomers.

Engineering a dimeric single-domain antibody for improved detection and neutralization of amyloid-β oligomers.

Journal: Communications biology

Published: June 19, 2025

Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.

Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates.

Journal: Cell & bioscience

Published: February 06, 2025

Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation.

Understanding liquid-liquid phase separation through TDP-43: fundamental principles, subcellular compartmentalisation, and role of solid inclusion formation.

Journal: Genome biology

Published: December 23, 2024

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease.

Telomeric DNA damage response mediates neurotoxicity of Aβ42 oligomers in Alzheimer's disease.

Journal: The EMBO journal

Published: November 18, 2024

Editorial: Promising therapeutic strategies for Alzheimer's disease: a focus on amyloid-β targeting.

Editorial: Promising therapeutic strategies for Alzheimer's disease: a focus on amyloid-β targeting.

Journal: Frontiers in neuroscience

Published: April 10, 2024

Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain.

Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain.

Journal: Cellular & molecular biology letters

Published: December 18, 2023

Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort.

Putative novel CSF biomarkers of Alzheimer's disease based on the novel concept of generic protein misfolding and proteotoxicity: the PRAMA cohort.

Journal: Translational neurodegeneration

Published: October 10, 2023

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF.

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer's disease CSF.

Journal: Alzheimer's research & therapy

Published: October 04, 2023

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies.

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies.

Journal: Neural regeneration research

Published: June 07, 2023

Showing 1-12 of 33

Last Updated: 09/26/2026