Alessandra T. De Souza

Av. Carlos Chagas Filho, 373 Bloco L Subsolo
Cidade Universitaria, RJ, Brazil

Last Updated: 09/26/2026

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Found 24 publications

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Predicted Enhanced Affinity for the Parasite Target cTXNPx.

Cross-Species Hepatic Metabolism of the Antileishmanial Chalcone NAT22 Generates Metabolites with Predicted Enhanced Affinity for the Parasite Target cTXNPx.

Journal: Pharmaceutics

Published: March 01, 2026

Coumarin-dihydropyrimidinone hybrids as promising agents against ovarian cancer: synthesis, SAR, and in silico evaluation.

Coumarin-dihydropyrimidinone hybrids as promising agents against ovarian cancer: synthesis, SAR, and in silico evaluation.

Journal: Bioorganic & medicinal chemistry letters

Published: February 11, 2026

Multitarget-directed ligands in Alzheimer's disease: identification of AChE and BACE1 inhibitors by in silico approaches.

Multitarget-directed ligands in Alzheimer's disease: identification of AChE and BACE1 inhibitors by in silico approaches.

Journal: Journal of computer-aided molecular design

Published: April 08, 2025

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches.

Unveiling Novel Arginase Inhibitors for Cutaneous Leishmaniasis Using Drug Repurposing and Virtual Screening Approaches.

Journal: Journal of cellular biochemistry

Published: March 24, 2025

CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson's disease models.

CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson's disease models.

Journal: Journal of neuroinflammation

Published: August 13, 2024

Evaluation of Biological Activities of Quinone-4-oxoquinoline Derivatives against Pathogens of Clinical Importance.

Evaluation of Biological Activities of Quinone-4-oxoquinoline Derivatives against Pathogens of Clinical Importance.

Journal: Current topics in medicinal chemistry

Published: December 16, 2021

Alternative Methods for Pulmonary-Administered Drugs Metabolism: A Breath of Change.

Alternative Methods for Pulmonary-Administered Drugs Metabolism: A Breath of Change.

Journal: Mini reviews in medicinal chemistry

Published: December 10, 2021

Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis.

Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis.

Journal: Bioorganic & medicinal chemistry

Published: August 18, 2021

DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium.

DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

Published: April 30, 2021

Structural insights into the allosteric site of Arabidopsis NADP-malic enzyme 2: role of the second sphere residues in the regulatory signal transmission.

Structural insights into the allosteric site of Arabidopsis NADP-malic enzyme 2: role of the second sphere residues in the regulatory signal transmission.

Journal: Plant molecular biology

Published: February 19, 2021

Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors.

Design, synthesis, in vitro and in silico studies of novel 4-oxoquinoline ribonucleoside derivatives as HIV-1 reverse transcriptase inhibitors.

Journal: European journal of medicinal chemistry

Published: November 05, 2019

Nanoparticles Loaded with a New Thiourea Derivative: Development and In vitro Evaluation Against Leishmania amazonensis.

Nanoparticles Loaded with a New Thiourea Derivative: Development and In vitro Evaluation Against Leishmania amazonensis.

Journal: Current drug delivery

Published: June 27, 2019

Showing 1-12 of 24

Last Updated: 09/26/2026