Alex F. Chen

138 Tong Zi Po Road
Changsha, 410013, China

Last Updated: 09/26/2026

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Found 129 publications

Endoplasmic Reticulum Stress-Induced Endothelial Cell Pyroptosis Contributes to Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension via IRE1α/Caspase-3/GSDME Pathway.

Endoplasmic Reticulum Stress-Induced Endothelial Cell Pyroptosis Contributes to Pulmonary Vascular Remodeling and Pulmonary Arterial Hypertension via IRE1α/Caspase-3/GSDME Pathway.

Journal: Journal of the American Heart Association

Published: July 10, 2026

Macrophage FTO deficiency accelerates atherosclerosis via PACS2-mediated activation of the PPARγ lipid signaling pathway.

Macrophage FTO deficiency accelerates atherosclerosis via PACS2-mediated activation of the PPARγ lipid signaling pathway.

Journal: Journal of translational medicine

Published: November 27, 2025

ASGR1 induces neutrophil extracellular traps formation to exacerbate sepsis-induced myocardial injury and cardiac dysfunction through SLC7A11 ubiquitination.

ASGR1 induces neutrophil extracellular traps formation to exacerbate sepsis-induced myocardial injury and cardiac dysfunction through SLC7A11 ubiquitination.

Journal: Clinical science (London, England : 1979)

Published: November 04, 2025

An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.

An Aberrant Resurgence of Endogenous Retroviruses Prompts Myocarditis and Heart Failure.

Journal: Circulation

Published: August 18, 2025

Inositol pyrophosphate kinases in health and disease.

Inositol pyrophosphate kinases in health and disease.

Journal: FEBS letters

Published: July 14, 2025

Alpha-ketoglutarate rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice.

Alpha-ketoglutarate rescues impaired endothelial progenitor cell-mediated angiogenesis in diabetic mice.

Journal: Frontiers in pharmacology

Published: June 30, 2025

PACS2 initiates foam cell formation in macrophages through the ROS-PPARγ-CD36 positive feedback loop.

PACS2 initiates foam cell formation in macrophages through the ROS-PPARγ-CD36 positive feedback loop.

Journal: Biochemical pharmacology

Published: May 01, 2025

ELABELA Targets Mitochondria to Modulate Heart Development.

ELABELA Targets Mitochondria to Modulate Heart Development.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: April 14, 2025

NR4A1 Acts as a Novel Regulator of Platelet Activation and Thrombus Formation.

NR4A1 Acts as a Novel Regulator of Platelet Activation and Thrombus Formation.

Journal: Circulation research

Published: March 04, 2025

Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.

Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia.

Journal: Cell reports

Published: February 26, 2025

Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD-Like Receptor Family Protein 3/Gasdermin E-Mediated Pyroptosis in Pulmonary Arterial Hypertension.

Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD-Like Receptor Family Protein 3/Gasdermin E-Mediated Pyroptosis in Pulmonary Arterial Hypertension.

Journal: Journal of the American Heart Association

Published: January 23, 2025

Ferroptosis-related genes MDM2 and CDKN1A as potential biomarkers for COPD.

Ferroptosis-related genes MDM2 and CDKN1A as potential biomarkers for COPD.

Journal: Journal of inflammation (London, England)

Published: December 01, 2024

Showing 1-12 of 129

Last Updated: 09/26/2026