Alexander M. Skeldon
4800 Rue Lévy #110
Quebec, QC H4R2P1, Canada
Quebec, QC H4R2P1, Canada
Last Updated: 09/26/2026
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Found 11 publications
Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization.
Journal: ACS medicinal chemistry letters
Published: September 30, 2024
Structural insight into the cGAS active site explains differences between therapeutically relevant species.
Journal: Communications chemistry
Published: September 22, 2024
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
Journal: Journal of medicinal chemistry
Published: February 01, 2024
Guiding ATR and PARP inhibitor combinationswith chemogenomic screens.
Journal: Cell reports
Published: December 15, 2021
RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors.
Journal: Molecular cancer therapeutics
Published: July 19, 2021
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Journal: Journal of immunology (Baltimore, Md. : 1950)
Published: July 07, 2015
A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.
Journal: Mucosal immunology
Published: October 28, 2014
Caspases and inflammasomes in metabolic inflammation.
Journal: Immunology and cell biology
Published: November 30, 2013
Cellular inhibitor of apoptosis protein cIAP2 protects against pulmonary tissue necrosis during influenza virus infection to promote host survival.
Journal: Cell host & microbe
Published: June 17, 2013
The inflammasome: in memory of Dr. Jurg Tschopp.
Journal: Cell death and differentiation
Published: November 15, 2011
The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages.
Journal: Cellular microbiology
Published: October 26, 2011
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Last Updated: 09/26/2026