Alexander S. Domling

A. Deusinglaan 1, 9713, AV
Groningen, GR, Netherlands

Last Updated: 09/26/2026

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Found 211 publications

Structure-based design of a 1H-Tetrazole-containing scaffold for Caspase-1 inhibition: Synthesis, biological evaluation, and preliminary in Vivo studies.

Structure-based design of a 1H-Tetrazole-containing scaffold for Caspase-1 inhibition: Synthesis, biological evaluation, and preliminary in Vivo studies.

Journal: Bioorganic & medicinal chemistry

Published: July 13, 2026

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules.

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules.

Journal: Journal of medicinal chemistry

Published: July 02, 2026

Structural and Biophysical Characterization of Aminobenzo[d]isothiazole 1,1-Dioxide SOS1 Ligands.

Structural and Biophysical Characterization of Aminobenzo[d]isothiazole 1,1-Dioxide SOS1 Ligands.

Journal: ACS medicinal chemistry letters

Published: May 31, 2026

An Ugi-Joullié Platform for Medicinally Relevant 1,4-Dihydrobenzothiazines.

An Ugi-Joullié Platform for Medicinally Relevant 1,4-Dihydrobenzothiazines.

Journal: ChemMedChem

Published: May 18, 2026

Geometry-dependent interfaces shape NLRP3 pyrin domain assembly.

Geometry-dependent interfaces shape NLRP3 pyrin domain assembly.

Journal: International journal of biological macromolecules

Published: May 15, 2026

Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension.

Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension.

Journal: ACS pharmacology & translational science

Published: February 18, 2026

A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling.

A small‑molecule HDAC/PDE modulator activates human adipocyte UCP1 and resolves inflammatory signaling.

Journal: Journal of translational medicine

Published: February 10, 2026

Ugi-Tetrazole-Derived α‑Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV‑2 3CLpro.

Ugi-Tetrazole-Derived α‑Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV‑2 3CLpro.

Journal: ACS medicinal chemistry letters

Published: December 23, 2025

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi.

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi.

Journal: ChemMedChem

Published: September 23, 2025

Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery.

Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery.

Journal: Green chemistry : an international journal and green chemistry resource : GC

Published: August 22, 2025

Disruption of NLRP3 inflammasome assembly via ligand-induced remodeling of pyrin domain interfaces.

Disruption of NLRP3 inflammasome assembly via ligand-induced remodeling of pyrin domain interfaces.

Journal: Scientific reports

Published: August 19, 2025

Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor.

Balinatunfib: A Clinical Oral Small Molecule TNFα Inhibitor.

Journal: ChemMedChem

Published: April 02, 2025

Showing 1-12 of 211

Last Updated: 09/26/2026