Alexandra L. Zakharenko

8, Acad. Lavrentjev Ave
Novosibirsk, NVS 630090, Russian Federation

Last Updated: 09/26/2026

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Found 62 publications

Synthesis and Biological Evaluation of TDP1 Inhibitors Based on Coumarin and Monoterpenoid Fragments Conjoined by Heterocyclic Moieties.

Synthesis and Biological Evaluation of TDP1 Inhibitors Based on Coumarin and Monoterpenoid Fragments Conjoined by Heterocyclic Moieties.

Journal: International journal of molecular sciences

Published: June 24, 2026

The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells.

The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells.

Journal: Current issues in molecular biology

Published: February 21, 2026

Special Issue "New Agents and Novel Drugs Use for the Oncological Diseases Treatment".

Special Issue "New Agents and Novel Drugs Use for the Oncological Diseases Treatment".

Journal: International journal of molecular sciences

Published: November 27, 2025

Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells.

Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells.

Journal: International journal of molecular sciences

Published: September 20, 2025

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2.

The effect of dimeric bisbenzimidazoles on the activity of DNA repair enzymes TDP1, TDP2, PARP1 and PARP2.

Journal: Vavilovskii zhurnal genetiki i selektsii

Published: August 07, 2025

Transcriptomic Analysis of TDP1-Knockout HEK293A Cells Treated with the TDP1 Inhibitor (Usnic Acid Derivative).

Transcriptomic Analysis of TDP1-Knockout HEK293A Cells Treated with the TDP1 Inhibitor (Usnic Acid Derivative).

Journal: International journal of molecular sciences

Published: August 01, 2025

Tissue distribution of OL9-116, a Tdp1 inhibitor based on usnic acid, is significantly altered in Lewis lung carcinoma-bearing mice compared to healthy animals.

Tissue distribution of OL9-116, a Tdp1 inhibitor based on usnic acid, is significantly altered in Lewis lung carcinoma-bearing mice compared to healthy animals.

Journal: Journal of pharmaceutical and biomedical analysis

Published: April 19, 2025

Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan

Amidothiazole Derivatives of (+)-Usnic Acid Effectively Inhibit TDP1 and Sensitize Tumor Cells to the Effects of Topotecan

Journal: Molekuliarnaia biologiia

Published: March 03, 2025

Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and Mechanism of Action.

Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and Mechanism of Action.

Journal: International journal of molecular sciences

Published: October 18, 2024

Novel Peptide-Drug Conjugates with Dual Anticancer Activity.

Novel Peptide-Drug Conjugates with Dual Anticancer Activity.

Journal: International journal of molecular sciences

Published: October 17, 2024

Transcriptomic analysis of HEK293A cells with a CRISPR/Cas9-mediated TDP1 knockout.

Transcriptomic analysis of HEK293A cells with a CRISPR/Cas9-mediated TDP1 knockout.

Journal: Biochimica et biophysica acta. General subjects

Published: December 25, 2023

Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives.

Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives.

Journal: International journal of molecular sciences

Published: November 22, 2023

Showing 1-12 of 62

Last Updated: 09/26/2026