Alexandre Orthwein

Mount Sinai Hospital, 600 University Avenue
Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 42 publications

mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.

mTOR inhibition enhances the antitumor efficacy of pan-RAF-MEK blockade by inhibiting the ATF4-MTHFD2 pathway.

Journal: Cell death & disease
Published: November 10, 2025

The role of tungsten in modulating DNA double-strand break repair and class switch recombination.

The role of tungsten in modulating DNA double-strand break repair and class switch recombination.

Journal: Toxicology and applied pharmacology
Published: April 01, 2025

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Journal: Nature
Published: January 29, 2025

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells.

Retraction Note: A mechanism for the suppression of homologous recombination in G1 cells.

Journal: Nature
Published: January 27, 2025

Retraction.

Retraction.

Journal: Science (New York, N.Y.)
Published: January 09, 2025

An E3 ubiquitin ligase localization screen uncovers DTX2 as a novel ADP-ribosylation-dependent regulator of DNA double-strand break repair.

An E3 ubiquitin ligase localization screen uncovers DTX2 as a novel ADP-ribosylation-dependent regulator of DNA double-strand break repair.

Journal: The Journal of biological chemistry
Published: May 31, 2024

Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.

Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node.

Journal: Research square
Published: March 18, 2024

Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node.

Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node.

Journal: Nature communications
Published: February 12, 2024

The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.

The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the γ-Subunit Gng2.

Journal: Molecular and cellular biology
Published: January 25, 2024

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling.

The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple-Negative Breast Cancer by Attenuating TGFβ Signaling.

Journal: Cancer research
Published: December 07, 2023

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.

The E3 ubiquitin ligase Herc1 modulates the response to nucleoside analogs in acute myeloid leukemia.

Journal: Blood advances
Published: August 28, 2023

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair.

Journal: Science advances
Published: August 09, 2023
Showing 1-12 of 42

Last Updated: 09/26/2026