Alexey V. Pshezhetsky

3640 University Street
Montreal, QC H3A0C7, Canada

Last Updated: 09/26/2026

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Found 60 publications

Cellular homeostasis of N-acetylneuraminic acid and non-canonical sialic acids is mediated by human N-acetylneuraminate lyase.

Cellular homeostasis of N-acetylneuraminic acid and non-canonical sialic acids is mediated by human N-acetylneuraminate lyase.

Journal: Glycobiology

Published: January 24, 2026

Mono-allelic p.R37H Dehydrodolichyl Diphosphate Synthase variants lead to protein glycosylation defects, aberrant lipid profiles and interneuron scarcity in a novel mouse model of progressive epileptic encephalopathy.

Mono-allelic p.R37H Dehydrodolichyl Diphosphate Synthase variants lead to protein glycosylation defects, aberrant lipid profiles and interneuron scarcity in a novel mouse model of progressive epileptic encephalopathy.

Journal: bioRxiv : the preprint server for biology

Published: September 02, 2025

Mucopolysaccharidosis Type IIIB With Pancytopenia: A Case Report and Hematological Correlations in Mice.

Mucopolysaccharidosis Type IIIB With Pancytopenia: A Case Report and Hematological Correlations in Mice.

Journal: Clinical genetics

Published: February 24, 2025

Cathepsin B inhibition blocks amyloidogenesis in the mouse models of neurological lysosomal diseases MPS IIIC and sialidosis.

Cathepsin B inhibition blocks amyloidogenesis in the mouse models of neurological lysosomal diseases MPS IIIC and sialidosis.

Journal: Molecular therapy. Methods & clinical development

Published: May 13, 2024

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins.

Secondary deficiency of neuraminidase 1 contributes to CNS pathology in neurological mucopolysaccharidoses via hypersialylation of brain glycoproteins.

Journal: bioRxiv : the preprint server for biology

Published: May 07, 2024

Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA.

Anti-amyloid treatment is broadly effective in neuronopathic mucopolysaccharidoses and synergizes with gene therapy in MPS-IIIA.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: May 03, 2024

Heterologous HSPC Transplantation Rescues Neuroinflammation and Ameliorates Peripheral Manifestations in the Mouse Model of Lysosomal Transmembrane Enzyme Deficiency, MPS IIIC.

Heterologous HSPC Transplantation Rescues Neuroinflammation and Ameliorates Peripheral Manifestations in the Mouse Model of Lysosomal Transmembrane Enzyme Deficiency, MPS IIIC.

Journal: Cells

Published: April 02, 2024

Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.

Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.

Journal: The Journal of clinical investigation

Published: January 26, 2024

Structure and mechanism of lysosome transmembrane acetylation by HGSNAT.

Structure and mechanism of lysosome transmembrane acetylation by HGSNAT.

Journal: Nature structural & molecular biology

Published: October 20, 2023

Severe central nervous system demyelination in Sanfilippo disease.

Severe central nervous system demyelination in Sanfilippo disease.

Journal: Frontiers in molecular neuroscience

Published: October 17, 2023

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.

N-acetylneuraminate pyruvate lyase controls sialylation of muscle glycoproteins essential for muscle regeneration and function.

Journal: Science advances

Published: June 30, 2023

Characterization of a phenotypically severe animal model for human AB-Variant GM2 gangliosidosis.

Characterization of a phenotypically severe animal model for human AB-Variant GM2 gangliosidosis.

Journal: Frontiers in molecular neuroscience

Published: June 19, 2023

Showing 1-12 of 60

Last Updated: 09/26/2026