Alisje Churchyard

London, ENG SW72AZ, United Kingdom

Last Updated: 09/26/2026

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Found 18 publications

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Journal: Journal of medicinal chemistry

Published: June 02, 2026

Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release.

Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release.

Journal: ACS nano

Published: October 06, 2025

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.

Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4.

Journal: Journal of medicinal chemistry

Published: April 14, 2025

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.

Journal: European journal of medicinal chemistry

Published: September 03, 2024

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex.

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc1 Complex.

Journal: ACS infectious diseases

Published: February 28, 2023

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4.

Journal: Journal of medicinal chemistry

Published: February 22, 2023

Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).

Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL).

Journal: ACS infectious diseases

Published: February 10, 2023

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.

Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy.

Journal: Science (New York, N.Y.)

Published: June 02, 2022

Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum.

Live-cell fluorescence imaging of microgametogenesis in the human malaria parasite Plasmodium falciparum.

Journal: PLoS pathogens

Published: October 07, 2021

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: August 16, 2021

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.

Journal: Nature communications

Published: May 17, 2021

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors.

Journal: ACS infectious diseases

Published: April 30, 2021

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Last Updated: 09/26/2026