Alla Y. Zenova

3650 Gilmore Way
Burnaby, BC V5G4W8, Canada

Last Updated: 09/26/2026

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Found 10 publications

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.

Journal: Bioorganic & medicinal chemistry letters

Published: September 20, 2024

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

Journal: British journal of pharmacology

Published: December 21, 2023

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

Journal: eLife

Published: July 24, 2021

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Journal: Bioorganic & medicinal chemistry letters

Published: April 07, 2021

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Journal: Journal of medicinal chemistry

Published: March 08, 2021

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

Journal: Journal of medicinal chemistry

Published: September 19, 2019

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.

Identification of Selective Acyl Sulfonamide-Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity.

Journal: Journal of medicinal chemistry

Published: December 01, 2018

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.

Journal: Journal of medicinal chemistry

Published: May 09, 2018

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7.

Journal: Bioorganic & medicinal chemistry letters

Published: July 18, 2014

Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.

Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.

Journal: Bioorganic & medicinal chemistry

Published: August 31, 2013

Showing 1-10 of 10

Last Updated: 09/26/2026