Allan C. Shaw
Sheffield, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 10 publications
C9orf72-ALS mutation drives basal mitophagy impairments in iNeurons.
Journal: Frontiers in cellular neuroscience
Published: October 24, 2025
M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis.
Journal: Molecular neurodegeneration
Published: June 24, 2025
Antisense oligonucleotide depletion of CCDC146 is a broad-spectrum therapeutic strategy for ALS.
Journal: medRxiv : the preprint server for health sciences
Published: April 18, 2024
C9ORF72 patient-derived endothelial cells drive blood-brain barrier disruption and contribute to neurotoxicity.
Journal: Fluids and barriers of the CNS
Published: December 18, 2023
Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer's disease astrocytes.
Journal: Molecular psychiatry
Published: June 26, 2023
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Journal: Frontiers in cellular neuroscience
Published: October 04, 2022
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.
Journal: Life science alliance
Published: October 26, 2021
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.
Journal: Aging cell
Published: April 02, 2020
C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.
Journal: Brain : a journal of neurology
Published: February 11, 2019
Showing 1-10 of 10
Last Updated: 09/26/2026