Amanda M. Mitchell

Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 25 publications

A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes in Drosophila melanogaster models.

A novel H2A-A127 variant is associated with human cancer and enhances tumor-related phenotypes in Drosophila melanogaster models.

Journal: Frontiers in oncology
Published: February 21, 2026

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation.

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation.

Journal: Blood cancer discovery
Published: December 06, 2024

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.

FLT3 is genetically essential for ITD-mutated leukemic stem cells but dispensable for human hematopoietic stem cells.

Journal: Blood
Published: June 21, 2024

Transposable elements shape stemness in normal and leukemic hematopoiesis.

Transposable elements shape stemness in normal and leukemic hematopoiesis.

Journal: Nature genetics
Published: May 23, 2024

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML.

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML.

Journal: bioRxiv : the preprint server for biology
Published: January 18, 2024

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.

KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition.

Journal: Leukemia
Published: September 14, 2022

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.

A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome.

Journal: Leukemia
Published: June 01, 2022

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia.

A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia.

Journal: Nature medicine
Published: July 27, 2021

A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia.

A clinical laboratory-developed LSC17 stemness score assay for rapid risk assessment of patients with acute myeloid leukemia.

Journal: Blood advances
Published: July 12, 2021

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.

Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.

Journal: Blood cancer discovery
Published: January 18, 2021

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining.

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining.

Journal: Nature communications
Published: June 23, 2020

CD200 expression marks leukemia stem cells in human AML.

CD200 expression marks leukemia stem cells in human AML.

Journal: Blood advances
Published: March 03, 2020
Showing 1-12 of 25

Last Updated: 09/26/2026