Amit Shard

Opposite Air Force Station
Ghandinagar, GJ 382355, India

Last Updated: 09/26/2026

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Found 51 publications

Coumarin-sulfonamide hybrids as PKM2 activators induce metabolic reprogramming and suppress ovarian cancer cell growth.

Coumarin-sulfonamide hybrids as PKM2 activators induce metabolic reprogramming and suppress ovarian cancer cell growth.

Journal: Bioorganic & medicinal chemistry

Published: May 21, 2026

2,5-Diazabicyclo[2.2.1]heptane in medicinal chemistry: a treasure trove of therapeutic opportunities.

2,5-Diazabicyclo[2.2.1]heptane in medicinal chemistry: a treasure trove of therapeutic opportunities.

Journal: RSC medicinal chemistry

Published: November 05, 2025

Recent progress in the development of small molecule pyruvate kinase M2 inhibitors: 2020-2025.

Recent progress in the development of small molecule pyruvate kinase M2 inhibitors: 2020-2025.

Journal: Future medicinal chemistry

Published: October 24, 2025

Rhynchophylline inhibits cluster of differentiation 36 (CD36) on endothelial cells to reduce fibrotic scar formation and enhance functional recovery after spinal cord injury.

Rhynchophylline inhibits cluster of differentiation 36 (CD36) on endothelial cells to reduce fibrotic scar formation and enhance functional recovery after spinal cord injury.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology

Published: October 23, 2025

Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer.

Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer.

Journal: Journal of medicinal chemistry

Published: October 01, 2025

Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy.

Mechanism-guided discovery of chromene-chalcone hybrids targeting PKM2 and microtubules for breast cancer therapy.

Journal: Bioorganic chemistry

Published: July 31, 2025

Pyruvate kinase M2 - linked metabolic pathways in pain modulation.

Pyruvate kinase M2 - linked metabolic pathways in pain modulation.

Journal: Drug discovery today

Published: June 10, 2025

IMID-284: a potent pyruvate kinase M2 inhibitor with dual anti-inflammatory and analgesic effects in intervertebral disc disease.

IMID-284: a potent pyruvate kinase M2 inhibitor with dual anti-inflammatory and analgesic effects in intervertebral disc disease.

Journal: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Published: May 07, 2025

Imidazopyrimidine-based pyruvate kinase M2 activator halts diabetic nephropathy progression via modulating epithelial-to-mesenchymal transition and fibrosis.

Imidazopyrimidine-based pyruvate kinase M2 activator halts diabetic nephropathy progression via modulating epithelial-to-mesenchymal transition and fibrosis.

Journal: Chemico-biological interactions

Published: March 10, 2025

Carbohydrate kinase inhibition: a promising strategy in cancer treatment.

Carbohydrate kinase inhibition: a promising strategy in cancer treatment.

Journal: Drug discovery today

Published: December 09, 2024

Synthesis, characterization, and microbiological evaluation of new triazolopyrimidine-based ferrocenes as potent antimicrobial prospects.

Synthesis, characterization, and microbiological evaluation of new triazolopyrimidine-based ferrocenes as potent antimicrobial prospects.

Journal: Journal of inorganic biochemistry

Published: November 25, 2024

Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells.

Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells.

Journal: Bioorganic chemistry

Published: October 03, 2024

Showing 1-12 of 51

Last Updated: 09/26/2026