Amy E. Chadwick
Liverpool, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 37 publications
Mitotoxic effects of the melanin-concentrating hormone receptor 1 (MCHr1) antagonist AZD1979 are influenced by mitochondrial DNA variation in HepG2 cybrids.
Journal: Toxicology
Published: September 25, 2025
Evaluating the use of rodents as in vitro, in vivo and ex vivo experimental models for the assessment of tyrosine kinase inhibitor-induced cardiotoxicity: a systematic review.
Journal: Archives of toxicology
Published: June 25, 2025
Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: November 04, 2024
Trimethylamine N-oxide (TMAO) acutely alters ionic currents but does not increase cardiac cell death.
Journal: Frontiers in physiology
Published: October 03, 2024
Glycolysis: An early marker for vancomycin-specific T-cell activation.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Published: September 12, 2023
Assessing the mitochondrial safety profile of the molnupiravir active metabolite, β-d-N4-hydroxycytidine (NHC), in the physiologically relevant HepaRG model.
Journal: Toxicology research
Published: July 26, 2023
Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis.
Journal: Biomedicines
Published: February 21, 2023
Selective protein kinase C inhibition switches time-dependent glucose cardiotoxicity to cardioprotection.
Journal: Frontiers in cardiovascular medicine
Published: July 18, 2022
Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: March 29, 2022
The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.
Journal: eLife
Published: February 25, 2022
The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review.
Journal: Frontiers in genetics
Published: April 22, 2021
Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury.
Journal: Chemical research in toxicology
Published: November 10, 2020
Last Updated: 09/26/2026