Amy E. Monaghan

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Journal: Journal of medicinal chemistry

Published: May 10, 2022

Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants.

Development of a High-Throughput Screening Assay for Small-Molecule Inhibitors of Androgen Receptor Splice Variants.

Journal: Assay and drug development technologies

Published: March 25, 2022

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

Journal: Journal of medicinal chemistry

Published: December 23, 2021

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Journal: Brain : a journal of neurology

Published: November 12, 2021

Structural Insights into Notum Covalent Inhibition.

Structural Insights into Notum Covalent Inhibition.

Journal: Journal of medicinal chemistry

Published: July 22, 2021

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.

Journal: Journal of medicinal chemistry

Published: October 30, 2020

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Journal: Journal of medicinal chemistry

Published: August 14, 2020

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.

Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila.

Journal: eLife

Published: May 04, 2020

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: September 05, 2019

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

Journal: MedChemComm

Published: February 15, 2019

A sting in the tail: the N-terminal domain of the androgen receptor as a drug target.

A sting in the tail: the N-terminal domain of the androgen receptor as a drug target.

Journal: Asian journal of andrology

Published: May 24, 2016

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.

International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.

Journal: Pharmacological reviews

Published: May 21, 2013

Showing 1-12 of 12

Last Updated: 09/26/2026