An Snellinx

Leuven, VLG, Belgium

Last Updated: 09/26/2026

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Found 20 publications

APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice.

APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice.

Journal: Cell reports
Published: February 04, 2026

Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice.

Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer's Disease Hallmarks in Chimeric Mice.

Journal: bioRxiv : the preprint server for biology
Published: February 20, 2025

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

Journal: Molecular neurodegeneration
Published: November 15, 2024

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

The Alzheimer's therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia.

Journal: Nature neuroscience
Published: July 30, 2024

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.

Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.

Journal: Cell reports
Published: May 16, 2024

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.

APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.

Journal: EMBO molecular medicine
Published: April 24, 2024

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease.

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease.

Journal: Science (New York, N.Y.)
Published: September 14, 2023

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.

Journal: Molecular neurodegeneration
Published: November 19, 2020

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Journal: Cell
Published: August 01, 2019

BACE2 distribution in major brain cell types and identification of novel substrates.

BACE2 distribution in major brain cell types and identification of novel substrates.

Journal: Life science alliance
Published: January 29, 2018

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

Journal: Neuron
Published: June 07, 2017

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments.

Journal: Molecular neurodegeneration
Published: August 18, 2016
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Last Updated: 09/26/2026