Andre Guillouzo
Rennes, France
Last Updated: 09/26/2026
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Found 31 publications
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Journal: Nature reviews. Drug discovery
Published: September 26, 2019
Setup and Use of HepaRG Cells in Cholestasis Research.
Journal: Methods in molecular biology (Clifton, N.J.)
Published: April 25, 2019
Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: January 11, 2019
Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics.
Journal: Toxicology in vitro : an international journal published in association with BIBRA
Published: December 01, 2018
A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: October 14, 2017
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes.
Journal: Free radical biology & medicine
Published: October 04, 2017
Progressive and Preferential Cellular Accumulation of Hydrophobic Bile Acids Induced by Cholestatic Drugs Is Associated with Inhibition of Their Amidation and Sulfation.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: July 06, 2017
From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology
Published: April 04, 2017
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways.
Journal: Scientific reports
Published: December 16, 2016
Early Alterations of Bile Canaliculi Dynamics and the Rho Kinase/Myosin Light Chain Kinase Pathway Are Characteristics of Drug-Induced Intrahepatic Cholestasis.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: May 04, 2016
Differential sensitivity of metabolically competent and non-competent HepaRG cells to apoptosis induced by diclofenac combined or not with TNF-α.
Journal: Toxicology letters
Published: January 19, 2016
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.
Journal: Scientific reports
Published: October 15, 2015
Last Updated: 09/26/2026