Andrea Guidarelli

Urbino, Italy

Last Updated: 09/26/2026

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Found 40 publications

Distinct Ca2+ pools regulate NADPH oxidase 2 activation driving Ca2+-independent mitochondrial ROS formation and mitochondrial permeability transition in arsenic trioxide-treated NB4 cells.

Distinct Ca2+ pools regulate NADPH oxidase 2 activation driving Ca2+-independent mitochondrial ROS formation and mitochondrial permeability transition in arsenic trioxide-treated NB4 cells.

Journal: Archives of toxicology

Published: October 27, 2025

Pyrazolone-based ERO1 inhibitors in ERO1-driven triple-negative breast cancer and SEPN1-related myopathy: Structure-activity relationship and therapeutic potential.

Pyrazolone-based ERO1 inhibitors in ERO1-driven triple-negative breast cancer and SEPN1-related myopathy: Structure-activity relationship and therapeutic potential.

Journal: Pharmacological research

Published: August 26, 2025

Myotube-specific vulnerability to clozapine.

Myotube-specific vulnerability to clozapine.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: August 07, 2025

Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria.

Clozapine blunts mitochondrial biogenesis in differentiating adipocytes: The increased ATP demand is met via stimulation of electron transport chain expression and activity in residual mitochondria.

Journal: Biochimica et biophysica acta. Molecular cell research

Published: November 07, 2024

Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment.

Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment.

Journal: Cell death & disease

Published: September 18, 2024

Unveiling the link between NADPH oxidase 2 activation and mitochondrial superoxide formation in leukemic cell killing induced by arsenic trioxide.

Unveiling the link between NADPH oxidase 2 activation and mitochondrial superoxide formation in leukemic cell killing induced by arsenic trioxide.

Journal: Pharmacological research

Published: August 29, 2024

ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation.

ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca2+ release sequentially triggering two different mechanisms of ROS formation.

Journal: Chemico-biological interactions

Published: August 02, 2023

Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells.

Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells.

Journal: Redox biology

Published: July 21, 2023

Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation.

Nrf2-Mediated Pathway Activated by Prunus spinosa L. (Rosaceae) Fruit Extract: Bioinformatics Analyses and Experimental Validation.

Journal: Nutrients

Published: April 04, 2023

Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms.

Arsenite enhances ERO1α expression via ryanodine receptor dependent and independent mechanisms.

Journal: Environmental toxicology and pharmacology

Published: September 19, 2022

Loss-of-rescue of Ryr1I4895T-related pathology by the genetic inhibition of the ER stress response mediator CHOP.

Loss-of-rescue of Ryr1I4895T-related pathology by the genetic inhibition of the ER stress response mediator CHOP.

Journal: Scientific reports

Published: August 14, 2022

Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity.

Inhibition of activity/expression, or genetic deletion, of ERO1α blunts arsenite geno- and cyto-toxicity.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Published: April 21, 2022

Showing 1-12 of 40

Last Updated: 09/26/2026