Andreas A. Hombach

Bernhard Nocht St. 74
Hamburg, HH 20359, Germany

Last Updated: 09/26/2026

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Found 36 publications

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function.

Journal: Journal for immunotherapy of cancer

Published: November 06, 2024

CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation.

CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation.

Journal: Frontiers in immunology

Published: November 28, 2022

A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2+ Solid Cancer.

A CD19-Anti-ErbB2 scFv Engager Protein Enables CD19-Specific CAR T Cells to Eradicate ErbB2+ Solid Cancer.

Journal: Cells

Published: November 11, 2022

IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors.

IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: October 19, 2020

Anti-CD19 CAR T cells potently redirected to kill solid tumor cells.

Anti-CD19 CAR T cells potently redirected to kill solid tumor cells.

Journal: PloS one

Published: April 02, 2020

IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells.

IL7-IL12 Engineered Mesenchymal Stem Cells (MSCs) Improve A CAR T Cell Attack Against Colorectal Cancer Cells.

Journal: Cells

Published: February 18, 2020

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir.

Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir.

Journal: Medical microbiology and immunology

Published: September 16, 2019

Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30- Tumors.

Blocking CD30 on T Cells by a Dual Specific CAR for CD30 and Colon Cancer Antigens Improves the CAR T Cell Response against CD30- Tumors.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: November 21, 2018

Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform.

Functionality and Cell Senescence of CD4/ CD8-Selected CD20 CAR T Cells Manufactured Using the Automated CliniMACS Prodigy® Platform.

Journal: Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Published: July 18, 2018

CD28-ζ CAR T Cells Resist TGF-β Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop.

CD28-ζ CAR T Cells Resist TGF-β Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: January 24, 2018

CD20-CD19 Bispecific CAR T Cells for the Treatment of B-Cell Malignancies.

CD20-CD19 Bispecific CAR T Cells for the Treatment of B-Cell Malignancies.

Journal: Human gene therapy

Published: December 07, 2017

Most Do, but Some Do Not: CD4⁺CD25- T Cells, but Not CD4⁺CD25⁺ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR).

Most Do, but Some Do Not: CD4⁺CD25- T Cells, but Not CD4⁺CD25⁺ Treg Cells, Are Cytolytic When Redirected by a Chimeric Antigen Receptor (CAR).

Journal: Cancers

Published: June 30, 2017

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Last Updated: 09/26/2026