Andreas C. Joerger

Max Von Laue Str. 15
Frankfurt Am Main, HE 60438, Germany

Last Updated: 09/26/2026

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Found 53 publications

In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity.

In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: May 21, 2026

DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants.

DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: April 28, 2026

Fragility of precision: resistance to mutant p53 reactivation.

Fragility of precision: resistance to mutant p53 reactivation.

Journal: Signal transduction and targeted therapy

Published: March 26, 2026

Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification.

Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification.

Journal: Cell death & disease

Published: September 22, 2025

Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt.

Targeting the p53 cancer mutants Y220C, Y220N, and Y220S with the small-molecule stabilizer rezatapopt.

Journal: Cell death & disease

Published: August 12, 2025

Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design.

Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design.

Journal: Journal of structural biology: X

Published: June 02, 2025

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

Journal: Journal of medicinal chemistry

Published: April 17, 2025

Enantioselective protein affinity selection mass spectrometry (E-ASMS).

Enantioselective protein affinity selection mass spectrometry (E-ASMS).

Journal: Nature communications

Published: February 06, 2025

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).

Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).

Journal: bioRxiv : the preprint server for biology

Published: February 03, 2025

Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.

Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 19, 2024

TP53: the unluckiest of genes?

TP53: the unluckiest of genes?

Journal: Cell death and differentiation

Published: May 10, 2024

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutations.

Journal: Nature genetics

Published: March 17, 2024

Showing 1-12 of 53

Last Updated: 09/26/2026