Anja Capell

Munich, BY, Germany

Last Updated: 09/26/2026

Save publications for later
Sign Up
Not sure about your diagnosis?
Check Your Symptoms
Found 25 publications

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism.

Journal: Nature communications
Published: September 08, 2024

Physiological shedding and C-terminal proteolytic processing of TMEM106B.

Physiological shedding and C-terminal proteolytic processing of TMEM106B.

Journal: Cell reports
Published: June 17, 2024

Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.

Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.

Journal: Science translational medicine
Published: June 05, 2024

Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.

Lack of a protective effect of the Tmem106b "protective SNP" in the Grn knockout mouse model for frontotemporal lobar degeneration.

Journal: Acta neuropathologica communications
Published: January 02, 2023

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.

Beneficial Effect of ACI-24 Vaccination on Aβ Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.

Journal: Cells
Published: November 14, 2022

Depletion and activation of microglia impact metabolic connectivity of the mouse brain.

Depletion and activation of microglia impact metabolic connectivity of the mouse brain.

Journal: Journal of neuroinflammation
Published: July 03, 2022

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.

A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.

Journal: Nature neuroscience
Published: April 14, 2022

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency.

Journal: The EMBO journal
Published: July 01, 2021

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice.

Journal: EMBO reports
Published: February 17, 2020

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

Journal: EMBO molecular medicine
Published: May 25, 2019

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.

The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons.

Journal: Cell reports
Published: February 14, 2019

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.

Journal: EMBO molecular medicine
Published: November 29, 2018
Showing 1-12 of 25

Last Updated: 09/26/2026