Ann-sofie Jemth

Stockholm, AB, Sweden

Last Updated: 09/26/2026

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Found 48 publications

Structural basis for uracil removal from DNA by human SMUG1.

Structural basis for uracil removal from DNA by human SMUG1.

Journal: Nature communications

Published: October 27, 2025

A monofunctional-like mutant of DNA glycosylase NTHL1 changes the dynamics of DNA repair during acute oxidative stress.

A monofunctional-like mutant of DNA glycosylase NTHL1 changes the dynamics of DNA repair during acute oxidative stress.

Journal: The Journal of biological chemistry

Published: October 27, 2025

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1.

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1.

Journal: FEBS letters

Published: March 31, 2025

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1.

Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1.

Journal: RSC chemical biology

Published: December 31, 2024

The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342.

The N-terminal SAM domain of the dNTPase SAMHD1 is not required for inhibition by small molecule TH6342.

Journal: Nucleosides, nucleotides & nucleic acids

Published: June 03, 2024

Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.

Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.

Journal: The FEBS journal

Published: January 12, 2024

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.

Journal: iScience

Published: November 12, 2022

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.

Journal: Nature metabolism

Published: August 12, 2022

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.

Journal: Science (New York, N.Y.)

Published: June 23, 2022

The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.

The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.

Journal: ChemMedChem

Published: May 18, 2022

Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.

Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.

Journal: The Journal of biological chemistry

Published: March 22, 2022

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.

NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.

Journal: Cell chemical biology

Published: March 22, 2021

Showing 1-12 of 48

Last Updated: 09/26/2026