Anna G. Sigurdardottir

Oncology R&D
Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis.

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis.

Journal: mAbs

Published: April 15, 2026

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release.

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release.

Journal: Journal for immunotherapy of cancer

Published: July 07, 2025

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.

Robust prediction of relative binding energies for protein-protein complex mutations using free energy perturbation calculations.

Journal: bioRxiv : the preprint server for biology

Published: May 07, 2024

Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations.

Robust Prediction of Relative Binding Energies for Protein-Protein Complex Mutations Using Free Energy Perturbation Calculations.

Journal: Journal of molecular biology

Published: April 25, 2024

A simeprevir-inducible molecular switch for the control of cell and gene therapies.

A simeprevir-inducible molecular switch for the control of cell and gene therapies.

Journal: Nature communications

Published: November 15, 2022

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.

Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.

Journal: Cell

Published: December 12, 2017

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors.

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors.

Journal: Nature structural & molecular biology

Published: May 05, 2017

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.

Journal: Chemical science

Published: June 15, 2015

Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.

Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach.

Journal: Molecular cancer therapeutics

Published: June 02, 2015

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.

Journal: Science (New York, N.Y.)

Published: April 11, 2015

An inducible chaperone adapts proteasome assembly to stress.

An inducible chaperone adapts proteasome assembly to stress.

Journal: Molecular cell

Published: March 03, 2014

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery.

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery.

Journal: Quarterly reviews of biophysics

Published: September 14, 2012

Showing 1-12 of 12

Last Updated: 09/26/2026