Ansgar A. Wegener

Frankfurter Str. 250
Darmstadt, HE 64293, Germany

Last Updated: 09/26/2026

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Found 16 publications

On the Scope of DCAF1-Recruiting PROTACs Degrading Protein Kinases.

On the Scope of DCAF1-Recruiting PROTACs Degrading Protein Kinases.

Journal: Journal of medicinal chemistry

Published: June 17, 2026

An engineered cereblon optimized for high-throughput screening and molecular glue discovery.

An engineered cereblon optimized for high-throughput screening and molecular glue discovery.

Journal: Cell chemical biology

Published: May 15, 2024

Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.

Extract2Chip-Bypassing Protein Purification in Drug Discovery Using Surface Plasmon Resonance.

Journal: Biosensors

Published: August 20, 2023

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 05, 2023

Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.

Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding.

Journal: The Journal of biological chemistry

Published: January 24, 2023

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.

Journal: ChemMedChem

Published: November 14, 2022

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.

Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.

Journal: Journal for immunotherapy of cancer

Published: June 15, 2022

Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.

Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology.

Journal: Journal of medicinal chemistry

Published: August 12, 2021

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

Journal: Journal of medicinal chemistry

Published: July 13, 2021

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.

Journal: Journal of chemical information and modeling

Published: August 20, 2020

Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.

Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.

Journal: Journal of medicinal chemistry

Published: November 15, 2019

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells.

Journal: The Journal of biological chemistry

Published: October 21, 2018

Showing 1-12 of 16

Last Updated: 09/26/2026