Aoife C. Murray

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 16 publications

BRD4 represses developmental and neuronal genes through interaction with PRC1.6.

BRD4 represses developmental and neuronal genes through interaction with PRC1.6.

Journal: bioRxiv : the preprint server for biology
Published: August 20, 2026

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models.

Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models.

Journal: Cell death & disease
Published: March 20, 2026

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.

Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.

Journal: Nature communications
Published: April 01, 2025

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21.

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21.

Journal: BBA advances
Published: October 21, 2024

It's good to know what to BACE the specificity of your inhibitors on.

It's good to know what to BACE the specificity of your inhibitors on.

Journal: The Journal of clinical investigation
Published: August 15, 2024

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.

Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.

Journal: Molecular psychiatry
Published: July 06, 2023

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.

Journal: EBioMedicine
Published: February 02, 2023

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Journal: Molecular psychiatry
Published: July 17, 2021

Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering.

Localized delivery of CRISPR/dCas9 via layer-by-layer self-assembling peptide coating on nanofibers for neural tissue engineering.

Journal: Biomaterials
Published: June 25, 2020

Modeling Down syndrome in cells: From stem cells to organoids.

Modeling Down syndrome in cells: From stem cells to organoids.

Journal: Progress in brain research
Published: February 15, 2020

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Journal: Molecular psychiatry
Published: January 29, 2020

Correction: Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells.

Correction: Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells.

Journal: Biomaterials science
Published: May 03, 2019
Showing 1-12 of 16

Last Updated: 09/26/2026