Aran F. Labrijn
Utrecht, UT 3584CT, Netherlands
Last Updated: 09/26/2026
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Found 24 publications
A Kinetic Model of Antigen-Dependent IgG Oligomerization and Complement Binding.
Journal: Small science
Published: March 07, 2025
Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: October 22, 2024
Impact of structural modifications of IgG antibodies on effector functions.
Journal: Frontiers in immunology
Published: September 29, 2023
The Influence of Human IgG Subclass and Allotype on Complement Activation.
Journal: Journal of immunology (Baltimore, Md. : 1950)
Published: May 04, 2023
Mutation of the TGN1412 anti-CD28 monoclonal antibody lower hinge confers specific FcγRIIb binding and retention of super-agonist activity.
Journal: Immunology and cell biology
Published: December 27, 2022
Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity.
Journal: Journal for immunotherapy of cancer
Published: July 28, 2022
Overcoming Challenges for CD3-Bispecific Antibody Therapy in Solid Tumors.
Journal: Cancers
Published: December 14, 2020
FcγR Binding and ADCC Activity of Human IgG Allotypes.
Journal: Frontiers in immunology
Published: January 17, 2020
DuoBody-CD3xCD20 induces potent T-cell-mediated killing of malignant B cells in preclinical models and provides opportunities for subcutaneous dosing.
Journal: EBioMedicine
Published: September 12, 2019
Bispecific antibodies: a mechanistic review of the pipeline.
Journal: Nature reviews. Drug discovery
Published: June 09, 2019
CD3-Bispecific Antibody Therapy Turns Solid Tumors into Inflammatory Sites but Does Not Install Protective Memory.
Journal: Molecular cancer therapeutics
Published: June 20, 2018
Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies.
Journal: The Journal of biological chemistry
Published: October 05, 2017
Last Updated: 09/26/2026